A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

Open Access

Peer-reviewed

Research Article

Tamara Tsalkova,

Affiliation Department of Pharmacology and Toxicology and Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America
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Fang C. Mei,

Affiliation Department of Pharmacology and Toxicology and Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Xiaodong Cheng

* E-mail: xcheng@utmb.edu

Affiliation Department of Pharmacology and Toxicology and Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America
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Library screening
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cAMP signaling cascade
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Guanine nucleotide exchange factors
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Intracellular receptors
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Nucleotides
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High throughput screening
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Nucleotide receptor signaling
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Protein kinases
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