Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

Julia Eitel; Karolin Meixenberger; Claudia van Laak; Christine Orlovski; Andreas Hocke; Bernd Schmeck; Stefan Hippenstiel; Philippe Dje N'Guessan; Norbert Suttorp; Bastian Opitz

doi:10.1371/journal.pone.0030379

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Peer-reviewed

Research Article

Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

Julia Eitel ,

Contributed equally to this work with: Julia Eitel, Karolin Meixenberger, Claudia van Laak

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Karolin Meixenberger ,

Contributed equally to this work with: Julia Eitel, Karolin Meixenberger, Claudia van Laak

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Claudia van Laak ,

Contributed equally to this work with: Julia Eitel, Karolin Meixenberger, Claudia van Laak

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Christine Orlovski,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Andreas Hocke,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Bernd Schmeck,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Stefan Hippenstiel,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Philippe Dje N'Guessan,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Norbert Suttorp,

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯
Bastian Opitz

* E-mail: bastian.opitz@charite.de

Affiliation Department of Internal Medicine, Infectious Diseases and Pulmonary Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany
⨯

Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

Julia Eitel,
Karolin Meixenberger,
Claudia van Laak,
Christine Orlovski,
Andreas Hocke,
Bernd Schmeck,
Stefan Hippenstiel,
Philippe Dje N'Guessan,
Norbert Suttorp,
Bastian Opitz

Published: January 20, 2012
https://doi.org/10.1371/journal.pone.0030379

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Chlamydophila pneumoniae
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Small interfering RNA
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Inflammasomes
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Chlamydia infection
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Transfection
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Toll-like receptors
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Chlamydia
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Monocytes
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