Transcription Factor FoxO1 Is Essential for Enamel Biomineralization

Ross A. Poché; Ramaswamy Sharma; Monica D. Garcia; Aya M. Wada; Mark J. Nolte; Ryan S. Udan; Ji-Hye Paik; Ronald A. DePinho; John D. Bartlett; Mary E. Dickinson

doi:10.1371/journal.pone.0030357

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Open Access

Peer-reviewed

Research Article

Transcription Factor FoxO1 Is Essential for Enamel Biomineralization

Ross A. Poché,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
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Ramaswamy Sharma,

Affiliation Department of Cytokine Biology, Forsyth Institute, and Department of Developmental Biology, Harvard School of Dental Medicine, Cambridge, Massachusetts, United States of America
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Monica D. Garcia,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
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Aya M. Wada,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
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Mark J. Nolte,

Affiliation Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
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Ryan S. Udan,

Affiliation Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
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Ji-Hye Paik,

Affiliation Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, United States of America
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Ronald A. DePinho,

Affiliation Departments of Medical Oncology, Medicine, and Genetics, Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America
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John D. Bartlett,

Affiliation Department of Cytokine Biology, Forsyth Institute, and Department of Developmental Biology, Harvard School of Dental Medicine, Cambridge, Massachusetts, United States of America
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Mary E. Dickinson

* E-mail: mdickins@bcm.edu

Affiliations Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Transcription Factor FoxO1 Is Essential for Enamel Biomineralization

Ross A. Poché,
Ramaswamy Sharma,
Monica D. Garcia,
Aya M. Wada,
Mark J. Nolte,
Ryan S. Udan,
Ji-Hye Paik,
Ronald A. DePinho,
John D. Bartlett,
Mary E. Dickinson

Published: January 24, 2012
https://doi.org/10.1371/journal.pone.0030357

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Ameloblasts
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Incisors
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Teeth
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Phenotypes
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Transcription factors
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Extracellular matrix proteins
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Transcriptional control
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