Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents

Haining Lv; Jinhong Ren; Shuanggang Ma; Song Xu; Jing Qu; Zhenjia Liu; Qing Zhou; Xiaoguang Chen; Shishan Yu

doi:10.1371/journal.pone.0030342

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Peer-reviewed

Research Article

Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents

Haining Lv ,

Contributed equally to this work with: Haining Lv, Jinhong Ren

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Jinhong Ren ,

Contributed equally to this work with: Haining Lv, Jinhong Ren

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Shuanggang Ma,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Song Xu,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Jing Qu,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Zhenjia Liu,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Qing Zhou,

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Xiaoguang Chen ,

* E-mail: chxg@imm.ac.cn (XC); yushishan@imm.ac.cn (SY)

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯
Shishan Yu

* E-mail: chxg@imm.ac.cn (XC); yushishan@imm.ac.cn (SY)

Affiliation State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⨯

Synthesis, Biological Evaluation and Mechanism Studies of Deoxytylophorinine and Its Derivatives as Potential Anticancer Agents

Haining Lv,
Jinhong Ren,
Shuanggang Ma,
Song Xu,
Jing Qu,
Zhenjia Liu,
Qing Zhou,
Xiaoguang Chen,
Shishan Yu

Published: January 19, 2012
https://doi.org/10.1371/journal.pone.0030342

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