Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas

• Stephanie Puget ,

  Contributed equally to this work with: Stephanie Puget, Cathy Philippe

  Affiliations Department of Neurosurgery, Necker-Sick Children Hospital, University Paris V Descartes, Paris, France, Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Cathy Philippe ,

  Contributed equally to this work with: Stephanie Puget, Cathy Philippe

  Affiliation Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Dorine A. Bax,

  Affiliation Section of Pediatric Oncology, The Institute of Cancer Research/Royal Marsden Hospital, Sutton, Surrey, United Kingdom

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• Bastien Job,

  Affiliation Formation de Recherche en Evolution 2939 du Centre National de la Recherche Scientifique, Integrated Research Cancer Institute in Villejuif, University Paris XI, Villejuif, France

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• Pascale Varlet,

  Affiliation Team Glial Plasticity, Unite Mixte de Recherche 894 de l'Institut National de la Santé et de la Recherche Medicale and Department of Neuropathology, Sainte-Anne Hospital, University Paris V Descartes, Paris, France

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• Marie-Pierre Junier,

  Affiliation Team Glial Plasticity, Unite Mixte de Recherche 894 de l'Institut National de la Santé et de la Recherche Medicale and Department of Neuropathology, Sainte-Anne Hospital, University Paris V Descartes, Paris, France

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• Felipe Andreiuolo,

  Affiliation Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Dina Carvalho,

  Affiliations Section of Pediatric Oncology, The Institute of Cancer Research/Royal Marsden Hospital, Sutton, Surrey, United Kingdom, Life and Health Sciences Research Institute, University Do Minho, Braga, Portugal, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal

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• Ricardo Reis,

  Affiliation Life and Health Sciences Research Institute, University Do Minho, Braga, Portugal

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• Lea Guerrini-Rousseau,

  Affiliation Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Thomas Roujeau,

  Affiliation Department of Neurosurgery, Necker-Sick Children Hospital, University Paris V Descartes, Paris, France

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• Philippe Dessen,

  Affiliation Formation de Recherche en Evolution 2939 du Centre National de la Recherche Scientifique, Integrated Research Cancer Institute in Villejuif, University Paris XI, Villejuif, France

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• Catherine Richon,

  Affiliation Functional Genomics Unit, Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Vladimir Lazar,

  Affiliation Functional Genomics Unit, Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Gwenael Le Teuff,

  Affiliation Department of Biostatistics and Epidemiology, Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Christian Sainte-Rose,

  Affiliation Department of Neurosurgery, Necker-Sick Children Hospital, University Paris V Descartes, Paris, France

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• Birgit Geoerger,

  Affiliations Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Gilles Vassal,

  Affiliation Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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• Chris Jones,

  Affiliation Section of Pediatric Oncology, The Institute of Cancer Research/Royal Marsden Hospital, Sutton, Surrey, United Kingdom

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•  [ ... ],
• Jacques Grill

  * E-mail: grill@igr.fr

  Affiliations Unite Mixte de Recherche 8203 du Centre National de la Recherche Scientifique «Vectorology and Anticancer Therapeutics», Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France, Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, University Paris XI, Villejuif, France

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