Electrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa Values

Open Access

Peer-reviewed

Research Article

Chi-Ho Chan,

Affiliation Centre for Protein Science and Crystallography, School of Life Science, The Chinese University of Hong Kong, Hong Kong, China
⨯
Cecily C. Wilbanks,

Affiliation Center for Biotechnology and Interdisciplinary Studies, Departments of Biology, Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America
⨯
George I. Makhatadze,

Affiliation Center for Biotechnology and Interdisciplinary Studies, Departments of Biology, Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York, United States of America
⨯
Kam-Bo Wong

* E-mail: kbwong@cuhk.edu.hk

Affiliation Centre for Protein Science and Crystallography, School of Life Science, The Chinese University of Hong Kong, Hong Kong, China
⨯

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Crystal structure
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Electrostatics
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NMR spectroscopy
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Protein folding
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Gibbs free energy
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Protein denaturation
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Crystals
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