Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures

• Katharina Diepold,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Katrin Bomans,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Michael Wiedmann,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Boris Zimmermann,

  Affiliation Pharma Biotech Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Andreas Petzold,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Tilman Schlothauer,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Robert Mueller,

  Affiliation Late-Stage Pharmaceutical and Processing Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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• Bernd Moritz,

  Affiliation Analytical Research and Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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• Jan Olaf Stracke,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Michael Mølhøj,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Dietmar Reusch,

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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• Patrick Bulau

  * E-mail: patrick.bulau@roche.com

  Affiliation Pharma Research and Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany

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