Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination

Penghui Yang; Yueqiang Duan; Peirui Zhang; Zhiwei Li; Cheng Wang; Mei Dong; Chong Tang; Li Xing; Hongjing Gu; Zhongpeng Zhao; Xiufan Liu; Shaogeng Zhang; Xiliang Wang

doi:10.1371/journal.pone.0030252

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Open Access

Peer-reviewed

Research Article

Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination

Penghui Yang ,

Contributed equally to this work with: Penghui Yang, Yueqiang Duan, Peirui Zhang

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Yueqiang Duan ,

Contributed equally to this work with: Penghui Yang, Yueqiang Duan, Peirui Zhang

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Peirui Zhang ,

Contributed equally to this work with: Penghui Yang, Yueqiang Duan, Peirui Zhang

Affiliation Department of Hepatobiliary, 302 Military Hospital, Beijing, China
⨯
Zhiwei Li,

Affiliation Department of Hepatobiliary, 302 Military Hospital, Beijing, China
⨯
Cheng Wang,

Affiliation Medical College of Soochow University, Suzhou, China
⨯
Mei Dong,

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Chong Tang,

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Li Xing,

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Hongjing Gu,

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Zhongpeng Zhao,

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯
Xiufan Liu,

Affiliation Key Laboratory for Animal Infectious Diseases of Ministry of Agriculture, Yangzhou University, Yangzhou, China
⨯
Shaogeng Zhang ,

* E-mail: zhangsg302@hotmail.com (SZ); xiliangw@126.com (XW)

Affiliation Department of Hepatobiliary, 302 Military Hospital, Beijing, China
⨯
Xiliang Wang

* E-mail: zhangsg302@hotmail.com (SZ); xiliangw@126.com (XW)

Affiliation Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing, China
⨯

Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination

Penghui Yang,
Yueqiang Duan,
Peirui Zhang,
Zhiwei Li,
Cheng Wang,
Mei Dong,
Chong Tang,
Li Xing,
Hongjing Gu,
Zhongpeng Zhao

Published: January 18, 2012
https://doi.org/10.1371/journal.pone.0030252

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