Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models

• Jiunn-Min Shieh,

  Affiliation Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan

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• Tzu-Tang Wei,

  Affiliation Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

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• Yen-An Tang,

  Affiliation Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan

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• Sin-Ming Huang,

  Affiliation Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

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• Wei-Ling Wen,

  Affiliation Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

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• Mei-Yu Chen,

  Affiliation Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan

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• Hung-Chi Cheng,

  Affiliations Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan, Institute of Biochemistry, National Cheng Kung University, Tainan, Taiwan

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• Santosh B. Salunke,

  Affiliation Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

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• Ching-Shih Chen,

  Affiliation Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Pinpin Lin,

  Affiliation Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan

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• Chien-Tien Chen ,

  * E-mail: ycw5798@mail.ncku.edu.tw (Y-CW); ctchen@mx.nthu.edu.tw (C-TC)

  Affiliation Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

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• Yi-Ching Wang

  * E-mail: ycw5798@mail.ncku.edu.tw (Y-CW); ctchen@mx.nthu.edu.tw (C-TC)

  Affiliations Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan, Institute of Basic Medical Science, National Cheng Kung University, Tainan, Taiwan

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