Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

Manujendra N. Saha; Hua Jiang; Yijun Yang; Xiaoyun Zhu; Xiaoming Wang; Aaron D. Schimmer; Lugui Qiu; Hong Chang

doi:10.1371/journal.pone.0030215

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Research Article

Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

Manujendra N. Saha,

Affiliations Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Hua Jiang,

Affiliation Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University, Shanghai, China
⨯
Yijun Yang,

Affiliations Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Xiaoyun Zhu,

Affiliations Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
⨯
Xiaoming Wang,

Affiliation Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada
⨯
Aaron D. Schimmer,

Affiliation Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada
⨯
Lugui Qiu,

Affiliation Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⨯
Hong Chang

* E-mail: Hong.Chang@uhn.on.ca

Affiliations Division of Molecular and Cellular Biology, Toronto General Hospital Research Institute, Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Hematology and Medical Oncology, University Health Network, Toronto, Ontario, Canada
⨯

Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

Manujendra N. Saha,
Hua Jiang,
Yijun Yang,
Xiaoyun Zhu,
Xiaoming Wang,
Aaron D. Schimmer,
Lugui Qiu,
Hong Chang

Published: January 20, 2012
https://doi.org/10.1371/journal.pone.0030215

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11 Jan 2013
12:34 GMT
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Comment from PLOS ONE Posted by PLOS_ONE_Group on 11 Jan 2013 at 12:34 GMT

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Apoptosis
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c-Jun N-terminal kinase signaling cascade
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Small interfering RNA
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Multiple myeloma
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Cancer treatment
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Gene expression
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