Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Bhuvanesh Dave; Melissa D. Landis; Lacey E. Dobrolecki; Meng-Fen Wu; Xiaomei Zhang; Thomas F. Westbrook; Susan G. Hilsenbeck; Dan Liu; Michael T. Lewis; David J. Tweardy; Jenny C. Chang

doi:10.1371/journal.pone.0030207

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Open Access

Peer-reviewed

Research Article

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Bhuvanesh Dave,

Affiliation The Methodist Cancer Center, Houston, Texas, United States of America
⨯
Melissa D. Landis,

Affiliation The Methodist Cancer Center, Houston, Texas, United States of America
⨯
Lacey E. Dobrolecki,

Affiliation The Methodist Cancer Center, Houston, Texas, United States of America
⨯
Meng-Fen Wu,

Affiliation Lester and Sue Smith Breast Center, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Xiaomei Zhang,

Affiliation Lester and Sue Smith Breast Center, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Thomas F. Westbrook,

Affiliation Department of Biochemistry and Molecular Biology, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Susan G. Hilsenbeck,

Affiliation Lester and Sue Smith Breast Center, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Dan Liu,

Affiliation Department of Biochemistry and Molecular Biology, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Michael T. Lewis,

Affiliation Lester and Sue Smith Breast Center, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
David J. Tweardy,

Affiliation Department of Infectious Diseases, Departments of Molecular & Cellular Biology and Radiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jenny C. Chang

* E-mail: jcchang@tmhs.org

Affiliation The Methodist Cancer Center, Houston, Texas, United States of America
⨯

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

Bhuvanesh Dave,
Melissa D. Landis,
Lacey E. Dobrolecki,
Meng-Fen Wu,
Xiaomei Zhang,
Thomas F. Westbrook,
Susan G. Hilsenbeck,
Dan Liu,
Michael T. Lewis,
David J. Tweardy

Published: August 6, 2012
https://doi.org/10.1371/journal.pone.0030207

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