Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis

TingTing Yan; Qing Li; HuiTing Zhou; YueTao Zhao; ShuQin Yu; GuangLin Xu; ZhiMin Yin; ZhongJun Li; ZhiHui Zhao

doi:10.1371/journal.pone.0030110

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Peer-reviewed

Research Article

Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis

TingTing Yan ,

Contributed equally to this work with: TingTing Yan, Qing Li

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯
Qing Li ,

Contributed equally to this work with: TingTing Yan, Qing Li

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
⨯
HuiTing Zhou,

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯
YueTao Zhao,

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
⨯
ShuQin Yu,

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯
GuangLin Xu,

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯
ZhiMin Yin,

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯
ZhongJun Li ,

* E-mail: zjli@bjmu.edu.cn (ZL); zhaozhihui_1964@yahoo.com.cn (ZZ)

Affiliation State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
⨯
ZhiHui Zhao

* E-mail: zjli@bjmu.edu.cn (ZL); zhaozhihui_1964@yahoo.com.cn (ZZ)

Affiliation Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Jiangsu Province, China
⨯

Gu-4 Suppresses Affinity and Avidity Modulation of CD11b and Improves the Outcome of Mice with Endotoxemia and Sepsis

TingTing Yan,
Qing Li,
HuiTing Zhou,
YueTao Zhao,
ShuQin Yu,
GuangLin Xu,
ZhiMin Yin,
ZhongJun Li,
ZhiHui Zhao

Published: February 2, 2012
https://doi.org/10.1371/journal.pone.0030110

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