Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

Christoph P. Hofstetter; Jan-Karl Burkhardt; Benjamin J. Shin; Demirkan B. Gürsel; Lynn Mubita; Ramana Gorrepati; Cameron Brennan; Eric C. Holland; John A. Boockvar

doi:10.1371/journal.pone.0030059

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Peer-reviewed

Research Article

Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

Christoph P. Hofstetter ,

* E-mail: chh9045@nyp.org

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
⨯
Jan-Karl Burkhardt,

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
⨯
Benjamin J. Shin,

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
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Demirkan B. Gürsel,

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
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Lynn Mubita,

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
⨯
Ramana Gorrepati,

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
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Cameron Brennan,

Affiliation Department of Neurosurgery and Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
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Eric C. Holland,

Affiliation Department of Neurosurgery and Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
John A. Boockvar

Affiliation Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
⨯

Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

Christoph P. Hofstetter,
Jan-Karl Burkhardt,
Benjamin J. Shin,
Demirkan B. Gürsel,
Lynn Mubita,
Ramana Gorrepati,
Cameron Brennan,
Eric C. Holland,
John A. Boockvar

Published: January 11, 2012
https://doi.org/10.1371/journal.pone.0030059

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Hypoxia
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Medical hypoxia
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Cyclins
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Apoptosis
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Malignant tumors
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Glioblastoma multiforme
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Protein expression
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Cell cycle and cell division
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