Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker; Melissa J. Walker; Nai-Kui Liu; Emelie C. Risberg; Xiang Gao; Jinhui Chen; Xiao-Ming Xu

doi:10.1371/journal.pone.0030012

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Peer-reviewed

Research Article

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker,

Affiliations Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Melissa J. Walker,

Affiliations Medical Neuroscience Graduate Program, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Nai-Kui Liu,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Emelie C. Risberg,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Xiang Gao,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Jinhui Chen,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Xiao-Ming Xu

* E-mail: xu26@iupui.edu

Affiliations Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Medical Neuroscience Graduate Program, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker,
Melissa J. Walker,
Nai-Kui Liu,
Emelie C. Risberg,
Xiang Gao,
Jinhui Chen,
Xiao-Ming Xu

Published: January 10, 2012
https://doi.org/10.1371/journal.pone.0030012

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Central nervous system
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Spinal cord injury
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Autophagic cell death
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Astrocytes
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Neurons
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Spinal cord
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