Discovery of T Cell Antigens by High-Throughput Screening of Synthetic Minigene Libraries

Brian D. Hondowicz; Katharine V. Schwedhelm; Arnold Kas; Michael A. Tasch; Crystal Rawlings; Nirasha Ramchurren; Martin McIntosh; Leonard A. D'Amico; Srinath Sanda; Nathan E. Standifer; Jay Shendure; Brad Stone

doi:10.1371/journal.pone.0029949

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Peer-reviewed

Research Article

Discovery of T Cell Antigens by High-Throughput Screening of Synthetic Minigene Libraries

Brian D. Hondowicz,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Katharine V. Schwedhelm,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Arnold Kas,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Michael A. Tasch,

Current address: Snoqualmie Ridge Kidney Center, Seattle, Washington, United States of America

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Crystal Rawlings,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Nirasha Ramchurren,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Martin McIntosh,

Affiliation Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Leonard A. D'Amico,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Srinath Sanda,

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯
Nathan E. Standifer,

Affiliation Clinical Immunology, Amgen, Seattle, Washington, United States of America
⨯
Jay Shendure,

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
⨯
Brad Stone

* E-mail: bstone@benaroyaresearch.org

Affiliation Translational Research Program, Benaroya Research Institute, Seattle, Washington, United States of America
⨯

Discovery of T Cell Antigens by High-Throughput Screening of Synthetic Minigene Libraries

Brian D. Hondowicz,
Katharine V. Schwedhelm,
Arnold Kas,
Michael A. Tasch,
Crystal Rawlings,
Nirasha Ramchurren,
Martin McIntosh,
Leonard A. D'Amico,
Srinath Sanda,
Nathan E. Standifer

Published: January 12, 2012
https://doi.org/10.1371/journal.pone.0029949

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T cells
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Gene pool
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Library screening
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Enzyme-linked immunoassays
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Transfection
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Antigen-presenting cells
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Cytotoxic T cells
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