The PI3-Kinase/mTOR-Targeting Drug NVP-BEZ235 Inhibits Growth and IgE-Dependent Activation of Human Mast Cells and Basophils

• Katharina Blatt,

  Affiliation Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria

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• Harald Herrmann,

  Affiliations Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, Ludwig Boltzmann Cluster Oncology, Vienna, Austria

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• Irina Mirkina,

  Affiliation Ludwig Boltzmann Cluster Oncology, Vienna, Austria

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• Emir Hadzijusufovic,

  Affiliations Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, Department for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria

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• Barbara Peter,

  Affiliations Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, Department for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Vienna, Austria

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• Sabine Strommer,

  Affiliation Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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• Gregor Hoermann,

  Affiliation Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

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• Matthias Mayerhofer,

  Affiliation Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria

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• Konrad Hoetzenecker,

  Affiliation Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria

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• Walter Klepetko,

  Affiliation Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria

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• Viviane Ghanim,

  Affiliation Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria

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• Katharina Marth,

  Affiliation Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria

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• Thorsten Füreder,

  Affiliation Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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• Volker Wacheck,

  Affiliation Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

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• Rudolf Valenta,

  Affiliation Christian Doppler Laboratory for Allergy Research, Division of Immunopathology, Department of Pathophysiology, Center for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria

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•  [ ... ],
• Peter Valent

  * E-mail: peter.valent@meduniwien.ac.at

  Affiliations Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, Ludwig Boltzmann Cluster Oncology, Vienna, Austria

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