The Shc Family Protein Adaptor, Rai, Negatively Regulates T Cell Antigen Receptor Signaling by Inhibiting ZAP-70 Recruitment and Activation

Open Access

Peer-reviewed

Research Article

Micol Ferro,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Maria Teresa Savino,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Barbara Ortensi,

Affiliation Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
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Francesca Finetti,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Luca Genovese,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Giulia Masi,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Cristina Ulivieri,

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Daniela Benati,

Current address: Department of Infection and Epidemiology, Institut Pasteur, Paris, France

Affiliation Department of Evolutionary Biology European Institute of Oncology, Milan, Italy
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Giuliana Pelicci,

Affiliation Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
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Cosima T. Baldari

* E-mail: cosima.baldari@unisi.it

Affiliations Department of Evolutionary Biology European Institute of Oncology, Milan, Italy, Istituto Toscano Tumori, University of Siena, Siena, Italy
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T cell receptors
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TCR signaling cascade
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Phosphorylation
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Immunoprecipitation
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T cells
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Transfection
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Immunoblot analysis
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Signal inhibition
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