Targeting RNA Polymerase Primary σ70 as a Therapeutic Strategy against Methicillin-Resistant Staphylococcus aureus by Antisense Peptide Nucleic Acid

Open Access

Peer-reviewed

Research Article

Targeting RNA Polymerase Primary σ⁷⁰ as a Therapeutic Strategy against Methicillin-Resistant Staphylococcus aureus by Antisense Peptide Nucleic Acid

Hui Bai ,

Contributed equally to this work with: Hui Bai, Guojun Sang, Yu You

Affiliations Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China, No. 451 Hospital, Xi'an, Shaanxi, China, Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, China
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Guojun Sang ,

Contributed equally to this work with: Hui Bai, Guojun Sang, Yu You

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Yu You ,

Contributed equally to this work with: Hui Bai, Guojun Sang, Yu You

Affiliation Department of Neurosurgery, No. 309 Hospital, Beijing, China
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Xiaoyan Xue,

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Ying Zhou,

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Zheng Hou,

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Jingru Meng,

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Xiaoxing Luo

* E-mail: xxluo3@fmmu.edu.cn

Affiliation Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China
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Staphylococcus aureus
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Methicillin-resistant Staphylococcus aureus
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Antibiotics
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Antisense RNA
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Epithelial cells
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Messenger RNA
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Antibacterials
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Gene expression
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