Low-Dosage Inhibition of Dll4 Signaling Promotes Wound Healing by Inducing Functional Neo-Angiogenesis

Alexandre Trindade; Dusan Djokovic; Joana Gigante; Marina Badenes; Ana-Rita Pedrosa; Ana-Carina Fernandes; Luís Lopes-da-Costa; Valery Krasnoperov; Ren Liu; Parkash S. Gill; António Duarte

doi:10.1371/journal.pone.0029863

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Open Access

Peer-reviewed

Research Article

Low-Dosage Inhibition of Dll4 Signaling Promotes Wound Healing by Inducing Functional Neo-Angiogenesis

Alexandre Trindade,

Affiliations Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Dusan Djokovic,

Affiliations Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Joana Gigante,

Affiliation Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal
⨯
Marina Badenes,

Affiliation Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal
⨯
Ana-Rita Pedrosa,

Affiliation Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal
⨯
Ana-Carina Fernandes,

Affiliation Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal
⨯
Luís Lopes-da-Costa,

Affiliation Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal
⨯
Valery Krasnoperov,

Affiliation Vasgene Therapeutics, Los Angeles, California, United States of America
⨯
Ren Liu,

Affiliation Department of Pathology, University of Southern California, Los Angeles, California, United States of America
⨯
Parkash S. Gill ,

* E-mail: parkashg@med.usc.edu (PSG); aduarte@fmv.utl.pt (AD)

Affiliations Department of Pathology, University of Southern California, Los Angeles, California, United States of America, Department of Medicine, University of Southern California, Los Angeles, California, United States of America
⨯
António Duarte

* E-mail: parkashg@med.usc.edu (PSG); aduarte@fmv.utl.pt (AD)

Affiliations Centro Interdisciplinar de Investigação em Sanidade Animal (CIISA), Lisbon Technical University, Lisbon, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯

Low-Dosage Inhibition of Dll4 Signaling Promotes Wound Healing by Inducing Functional Neo-Angiogenesis

Alexandre Trindade,
Dusan Djokovic,
Joana Gigante,
Marina Badenes,
Ana-Rita Pedrosa,
Ana-Carina Fernandes,
Luís Lopes-da-Costa,
Valery Krasnoperov,
Ren Liu,
Parkash S. Gill

Published: January 18, 2012
https://doi.org/10.1371/journal.pone.0029863

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Wound healing
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Gene expression
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Cancers and neoplasms
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Inflammation
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Angiogenesis
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Notch signaling
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Granulation tissue
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Blood vessels
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