Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Joan Villarroya; Beatriz Dorado; Maya R. Vilà; Elena Garcia-Arumí; Pere Domingo; Marta Giralt; Michio Hirano; Francesc Villarroya

doi:10.1371/journal.pone.0029691

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Peer-reviewed

Research Article

Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Joan Villarroya ,

* E-mail: joanvillarroya@gmail.com

Affiliations Departament de Bioquímica i Biologia Molecular, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain, Institut de Recerca de l′Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), ISCIII, Santiago de Compostela, Spain
⨯
Beatriz Dorado,

Affiliation Department of Neurology, Columbia University Medical Center, New York, New York, United States of America
⨯
Maya R. Vilà,

Affiliation Institut de Recerca de l′Hospital Universitari de la Vall d'Hebron, Barcelona, Spain
⨯
Elena Garcia-Arumí,

Affiliations Institut de Recerca de l′Hospital Universitari de la Vall d'Hebron, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Valencia, Spain
⨯
Pere Domingo,

Affiliation Institut de Recerca de l′Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯
Marta Giralt,

Affiliations Departament de Bioquímica i Biologia Molecular, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), ISCIII, Santiago de Compostela, Spain
⨯
Michio Hirano,

Affiliation Department of Neurology, Columbia University Medical Center, New York, New York, United States of America
⨯
Francesc Villarroya

Affiliations Departament de Bioquímica i Biologia Molecular, and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERObn), ISCIII, Santiago de Compostela, Spain
⨯

Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine Levels in Mice

Joan Villarroya,
Beatriz Dorado,
Maya R. Vilà,
Elena Garcia-Arumí,
Pere Domingo,
Marta Giralt,
Michio Hirano,
Francesc Villarroya

Published: December 27, 2011
https://doi.org/10.1371/journal.pone.0029691

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Mitochondrial DNA
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Brown adipose tissue
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Mitochondria
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Gene expression
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Adipose tissue
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Adipocytes
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Mouse models
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