Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells

Zenghui Teng; Chengjun Yuan; Feng Zhang; Menglei Huan; Weidong Cao; Kangchu Li; Jingyue Yang; Dayong Cao; Siyuan Zhou; Qibing Mei

doi:10.1371/journal.pone.0029647

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Peer-reviewed

Research Article

Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells

Zenghui Teng ,

Contributed equally to this work with: Zenghui Teng, Chengjun Yuan

Affiliation Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Chengjun Yuan ,

Contributed equally to this work with: Zenghui Teng, Chengjun Yuan

Affiliation Cardiovascular Department, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China
⨯
Feng Zhang,

Affiliation Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Menglei Huan,

Affiliation Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Weidong Cao,

Affiliation Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Kangchu Li,

Affiliation Department of Radiation Medicine, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Jingyue Yang,

Affiliation Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Dayong Cao,

Affiliation Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Siyuan Zhou ,

* E-mail: zhousiyuan1@hotmail.com (SZ); tengzenghui@hotmail.com (QM)

Affiliation Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
⨯
Qibing Mei

* E-mail: zhousiyuan1@hotmail.com (SZ); tengzenghui@hotmail.com (QM)

Affiliation Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, School of Pharmacy, Fourth Military Medical University, Xi'an, People's Republic of China
⨯

Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells

Zenghui Teng,
Chengjun Yuan,
Feng Zhang,
Menglei Huan,
Weidong Cao,
Kangchu Li,
Jingyue Yang,
Dayong Cao,
Siyuan Zhou,
Qibing Mei

Published: January 13, 2012
https://doi.org/10.1371/journal.pone.0029647

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