Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell

Wei Yu; Chengmeng Jin; Xiaoyan Lou; Xu Han; Lisha Li; Yinghua He; Hongyu Zhang; Kelong Ma; Jingde Zhu; Lihua Cheng; Biaoyang Lin

doi:10.1371/journal.pone.0029450

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Open Access

Peer-reviewed

Research Article

Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell

Wei Yu,

Affiliations Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China, Department of Biology, Technische Universität Darmstadt, Darmstadt Germany
⨯
Chengmeng Jin,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China
⨯
Xiaoyan Lou,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China
⨯
Xu Han,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China
⨯
Lisha Li,

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China
⨯
Yinghua He,

Affiliation Shanghai Cancer Institute/Renji Hospital, Shanghai Jiaotong Univisity, Shanghai, China
⨯
Hongyu Zhang,

Affiliation Shanghai Cancer Institute/Renji Hospital, Shanghai Jiaotong Univisity, Shanghai, China
⨯
Kelong Ma,

Affiliation Shanghai Cancer Institute/Renji Hospital, Shanghai Jiaotong Univisity, Shanghai, China
⨯
Jingde Zhu,

Affiliation Shanghai Cancer Institute/Renji Hospital, Shanghai Jiaotong Univisity, Shanghai, China
⨯
Lihua Cheng ,

* E-mail: bylin@u.washington.edu;biaoylin@gmail.com (BL); chenglihua75@gmail.com (LC)

Affiliation Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China
⨯
Biaoyang Lin

* E-mail: bylin@u.washington.edu;biaoylin@gmail.com (BL); chenglihua75@gmail.com (LC)

Affiliations Systems Biology Division, Zhejiang–California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang Providence, China, Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, United States of America, Department of Urology, University of Washington, Seattle, Washington, United States of America
⨯

Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell

Wei Yu,
Chengmeng Jin,
Xiaoyan Lou,
Xu Han,
Lisha Li,
Yinghua He,
Hongyu Zhang,
Kelong Ma,
Jingde Zhu,
Lihua Cheng

Published: December 22, 2011
https://doi.org/10.1371/journal.pone.0029450

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DNA methylation
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Ovarian cancer
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Human genomics
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Protein domains
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Epigenetics
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Gene expression
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MAPK signaling cascades
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Transcription factors
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