Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects

He Liu; Hong-Xing Zhang; Hui-Yan Hou; Xian-Fu Lu; Jing-Qiu Wei; Chun-Guang Wang; Li-Cai Zhang; Yin-Ming Zeng; Yong-Ping Wu; Jun-Li Cao

doi:10.1371/journal.pone.0029395

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Open Access

Peer-reviewed

Research Article

Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects

He Liu ,

Contributed equally to this work with: He Liu, Hong-Xing Zhang, Hui-Yan Hou

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Hong-Xing Zhang ,

Contributed equally to this work with: He Liu, Hong-Xing Zhang, Hui-Yan Hou

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Hui-Yan Hou ,

Contributed equally to this work with: He Liu, Hong-Xing Zhang, Hui-Yan Hou

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Xian-Fu Lu,

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Jing-Qiu Wei,

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Chun-Guang Wang,

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Li-Cai Zhang,

Affiliation Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
⨯
Yin-Ming Zeng,

Affiliations Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China, Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xu Zhou, China
⨯
Yong-Ping Wu,

Affiliation Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xu Zhou, China
⨯
Jun-Li Cao

* E-mail: caojl0310@yahoo.com.cn

Affiliations Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xu Zhou, China, Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xu Zhou, China
⨯

Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects

He Liu,
Hong-Xing Zhang,
Hui-Yan Hou,
Xian-Fu Lu,
Jing-Qiu Wei,
Chun-Guang Wang,
Li-Cai Zhang,
Yin-Ming Zeng,
Yong-Ping Wu,
Jun-Li Cao

Published: December 28, 2011
https://doi.org/10.1371/journal.pone.0029395

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