Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

Neira Sáinz; Amaia Rodríguez; Victoria Catalán; Sara Becerril; Beatriz Ramírez; Andoni Lancha; Emma Burgos-Ramos; Javier Gómez-Ambrosi; Gema Frühbeck

doi:10.1371/journal.pone.0029389

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Research Article

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

Neira Sáinz,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Amaia Rodríguez,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Victoria Catalán,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Sara Becerril,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Beatriz Ramírez,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Andoni Lancha,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Emma Burgos-Ramos,

Affiliations Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Javier Gómez-Ambrosi,

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯
Gema Frühbeck

* E-mail: gfruhbeck@unav.es

Affiliations Metabolic Research Laboratory, Universidad de Navarra, Pamplona, Spain, Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain, CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Pamplona, Spain
⨯

Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

Neira Sáinz,
Amaia Rodríguez,
Victoria Catalán,
Sara Becerril,
Beatriz Ramírez,
Andoni Lancha,
Emma Burgos-Ramos,
Javier Gómez-Ambrosi,
Gema Frühbeck

Published: January 9, 2012
https://doi.org/10.1371/journal.pone.0029389

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Leptin
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Skeletal muscles
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Membrane proteins
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Immunoprecipitation
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Glucose
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Insulin
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Cell membranes
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Phosphorylation
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