Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

• Dana Ungermannova ,

  Contributed equally to this work with: Dana Ungermannova, Seth J. Parker

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Seth J. Parker ,

  Contributed equally to this work with: Dana Ungermannova, Seth J. Parker

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Christopher G. Nasveschuk,

  Current address: Constellation Pharmaceuticals, Cambridge, Massachusetts, United States of America

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Wei Wang,

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Bettina Quade,

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Gan Zhang,

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Robert D. Kuchta,

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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• Andrew J. Phillips,

  Affiliation Department of Chemistry, Yale University, New Haven, Connecticut, United States of America

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• Xuedong Liu

  * E-mail: Xuedong.Liu@Colorado.edu

  Affiliation Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, United States of America

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