Permanent Neonatal Diabetes Caused by Creation of an Ectopic Splice Site within the INS Gene

Intza Garin; Guiomar Perez de Nanclares; Elena Gastaldo; Lorna W. Harries; Oscar Rubio-Cabezas; Luis Castaño

doi:10.1371/journal.pone.0029205

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Peer-reviewed

Research Article

Permanent Neonatal Diabetes Caused by Creation of an Ectopic Splice Site within the INS Gene

Intza Garin ,

Contributed equally to this work with: Intza Garin, Guiomar Perez de Nanclares

Affiliations Endocrinology and Diabetes Research Group, Hospital de Cruces, Universitat Politècnica de València/Euskal Herriko Unibertsitateko, Barakaldo, Bizkaia, Spain, Centro de Investingación Biomèdica en Red de Diabetes y Endermedades Metabólicas (CIBERDM), Centro de investigación Biomèdica en Red de Endermedads Raras (CIBERER), Barakaldo, Bizkaia, Spain
⨯
Guiomar Perez de Nanclares ,

Contributed equally to this work with: Intza Garin, Guiomar Perez de Nanclares

Affiliations Endocrinology and Diabetes Research Group, Hospital de Cruces, Universitat Politècnica de València/Euskal Herriko Unibertsitateko, Barakaldo, Bizkaia, Spain, Centro de Investingación Biomèdica en Red de Diabetes y Endermedades Metabólicas (CIBERDM), Centro de investigación Biomèdica en Red de Endermedads Raras (CIBERER), Barakaldo, Bizkaia, Spain
⨯
Elena Gastaldo,

Affiliation Pediatric Endocrinology, Hospital de La Ribera, Alzira, Valencia, Spain
⨯
Lorna W. Harries,

Affiliation Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, Exeter, United Kingdom
⨯
Oscar Rubio-Cabezas,

Affiliations Department of Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain, Centro de Investigación Biomédica en Red Fisiopatogía se la obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
⨯
Luis Castaño

* E-mail: lcastano@osakidetza.net

Affiliations Endocrinology and Diabetes Research Group, Hospital de Cruces, Universitat Politècnica de València/Euskal Herriko Unibertsitateko, Barakaldo, Bizkaia, Spain, Centro de Investingación Biomèdica en Red de Diabetes y Endermedades Metabólicas (CIBERDM), Centro de investigación Biomèdica en Red de Endermedads Raras (CIBERER), Barakaldo, Bizkaia, Spain
⨯

Permanent Neonatal Diabetes Caused by Creation of an Ectopic Splice Site within the INS Gene

Intza Garin,
Guiomar Perez de Nanclares,
Elena Gastaldo,
Lorna W. Harries,
Oscar Rubio-Cabezas,
Luis Castaño

Published: January 3, 2012
https://doi.org/10.1371/journal.pone.0029205

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Insertion mutation
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Birth weight
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Diabetes mellitus
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