Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

Hongyan Qin; Keiichiro Suzuki; Mikiyo Nakata; Shunsuke Chikuma; Nakako Izumi; Le Thi Huong; Mikako Maruya; Sidonia Fagarasan; Meinrad Busslinger; Tasuku Honjo; Hitoshi Nagaoka

doi:10.1371/journal.pone.0029141

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Peer-reviewed

Research Article

Activation-Induced Cytidine Deaminase Expression in CD4⁺ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

Hongyan Qin,

Current address: State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, China

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Keiichiro Suzuki,

Affiliation Laboratory for Mucosal Immunity, RIKEN, Yokohama, Japan
⨯
Mikiyo Nakata,

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Shunsuke Chikuma,

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Nakako Izumi,

Current address: Research Center for Charged Particle Therapy, Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba-shi, Japan

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Le Thi Huong,

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Mikako Maruya,

Affiliation Laboratory for Mucosal Immunity, RIKEN, Yokohama, Japan
⨯
Sidonia Fagarasan,

Affiliation Laboratory for Mucosal Immunity, RIKEN, Yokohama, Japan
⨯
Meinrad Busslinger,

Affiliation Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
⨯
Tasuku Honjo ,

* E-mail: honjo@mfour.med.kyoto-u.ac.jp (TH); nagaokh@gifu-u.ac.jp (HN)

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Hitoshi Nagaoka

* E-mail: honjo@mfour.med.kyoto-u.ac.jp (TH); nagaokh@gifu-u.ac.jp (HN)

Current address: Department of Molecular Pathobiochemistry, Graduate School of Medicine, Gifu University, Gifu, Japan

Affiliation Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯

Activation-Induced Cytidine Deaminase Expression in CD4⁺ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age

Hongyan Qin,
Keiichiro Suzuki,
Mikiyo Nakata,
Shunsuke Chikuma,
Nakako Izumi,
Le Thi Huong,
Mikako Maruya,
Sidonia Fagarasan,
Meinrad Busslinger,
Tasuku Honjo

Published: December 28, 2011
https://doi.org/10.1371/journal.pone.0029141

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