Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome

Prabhakar Rajan; Caroline Dalgliesh; Phillippa J. Carling; Thomas Buist; Chaolin Zhang; Sushma N. Grellscheid; Kelly Armstrong; Jacqueline Stockley; Cedric Simillion; Luke Gaughan; Gabriela Kalna; Michael Q. Zhang; Craig N. Robson; Hing Y. Leung; David J. Elliott

doi:10.1371/journal.pone.0029088

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Open Access

Peer-reviewed

Research Article

Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome

Prabhakar Rajan ,

Contributed equally to this work with: Prabhakar Rajan, Caroline Dalgliesh

Affiliations Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Beatson Institute for Cancer Research, Glasgow, United Kingdom, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Caroline Dalgliesh ,

Contributed equally to this work with: Prabhakar Rajan, Caroline Dalgliesh

Affiliation Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Phillippa J. Carling,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Thomas Buist,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Chaolin Zhang,

Current address: Howard Hughes Medical Institute, Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, United States of America

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
⨯
Sushma N. Grellscheid,

Affiliation Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Kelly Armstrong,

Affiliation Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Jacqueline Stockley,

Affiliation Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Cedric Simillion,

Affiliation Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Luke Gaughan,

Affiliation Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Gabriela Kalna,

Affiliation Beatson Institute for Cancer Research, Glasgow, United Kingdom
⨯
Michael Q. Zhang,

Current address: Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas, United States of America

Affiliation Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
⨯
Craig N. Robson,

Affiliation Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Hing Y. Leung,

Affiliations Beatson Institute for Cancer Research, Glasgow, United Kingdom, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
David J. Elliott

* E-mail: david.elliott@ncl.ac.uk

Affiliation Institute of Human Genetics, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯

Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome

Prabhakar Rajan,
Caroline Dalgliesh,
Phillippa J. Carling,
Thomas Buist,
Chaolin Zhang,
Sushma N. Grellscheid,
Kelly Armstrong,
Jacqueline Stockley,
Cedric Simillion,
Luke Gaughan

Published: December 14, 2011
https://doi.org/10.1371/journal.pone.0029088

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Messenger RNA
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Androgens
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Gene expression
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