Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data

• Benjamin Werner ,

  * E-mail: werner@evolbio.mpg.de

  Affiliation Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Plön, Germany

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• David Lutz,

  Affiliation Department of Oncology, Hematology, Bone Marrow Transplantation and Pneumology, Hubertus Wald Tumor Zentrum, University Hospital Eppendorf, Hamburg, Germany

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• Tim H. Brümmendorf,

  Affiliation Department Hematology and Oncology, RWTH Medical School, Aachen, Germany

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• Arne Traulsen,

  Affiliation Evolutionary Theory Group, Max-Planck-Institute for Evolutionary Biology, Plön, Germany

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• Stefan Balabanov

  Affiliation Department of Oncology, Hematology, Bone Marrow Transplantation and Pneumology, Hubertus Wald Tumor Zentrum, University Hospital Eppendorf, Hamburg, Germany

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