Cigarette Smoking and p16INK4α Gene Promoter Hypermethylation in Non-Small Cell Lung Carcinoma Patients: A Meta-Analysis

Bo Zhang; Wei Zhu; Ping Yang; Tao Liu; Mei Jiang; Zhi-Ni He; Shi-Xin Zhang; Wei-Qing Chen; Wen Chen

doi:10.1371/journal.pone.0028882

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Open Access

Peer-reviewed

Research Article

Cigarette Smoking and p16^INK4α Gene Promoter Hypermethylation in Non-Small Cell Lung Carcinoma Patients: A Meta-Analysis

Bo Zhang ,

Contributed equally to this work with: Bo Zhang, Wei Zhu

Affiliation Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Wei Zhu ,

Contributed equally to this work with: Bo Zhang, Wei Zhu

Affiliation Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China
⨯
Ping Yang,

Affiliation Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Tao Liu,

Affiliations Faculty of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China, Guangdong Institute of Public Health, Guangzhou, China, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China
⨯
Mei Jiang,

Affiliation Faculty of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Zhi-Ni He,

Affiliation Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Shi-Xin Zhang,

Affiliation Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Wei-Qing Chen ,

* E-mail: chenwq@mail.sysu.edu.cn (W-QC); chenwen@mail.sysu.edu.cn (WC)

Affiliation Faculty of Biostatistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯
Wen Chen

* E-mail: chenwq@mail.sysu.edu.cn (W-QC); chenwen@mail.sysu.edu.cn (WC)

Affiliation Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China
⨯

Cigarette Smoking and p16^INK4α Gene Promoter Hypermethylation in Non-Small Cell Lung Carcinoma Patients: A Meta-Analysis

Bo Zhang,
Wei Zhu,
Ping Yang,
Tao Liu,
Mei Jiang,
Zhi-Ni He,
Shi-Xin Zhang,
Wei-Qing Chen,
Wen Chen

Published: December 13, 2011
https://doi.org/10.1371/journal.pone.0028882

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Non-small cell lung cancer
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DNA methylation
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Lung and intrathoracic tumors
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Smoking habits
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Methylation
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Metaanalysis
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Adenocarcinoma of the lung
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