Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans

• Wai-Jiao Cai ,

  Contributed equally to this work with: Wai-Jiao Cai, Jian-Hua Huang

  Affiliations Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China, Buck Institute for Research on Aging, Novato, California, United States of America

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• Jian-Hua Huang ,

  Contributed equally to this work with: Wai-Jiao Cai, Jian-Hua Huang

  Affiliation Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China

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• Su-Qin Zhang,

  Affiliations Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China, Clinical Medicine College of Hangzhou Normal University & The Second Hospital of Hangzhou affiliated to Hangzhou Normal University, Hangzhou, China

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• Bin Wu,

  Affiliation Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China

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• Pankaj Kapahi ,

  * E-mail: pkapahi@buckinstitute.org (PK); xmzhang54@yahoo.com (X-MZ); ziyinshen@126.com (Z-YS)

  Affiliation Buck Institute for Research on Aging, Novato, California, United States of America

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• Xin-Min Zhang ,

  * E-mail: pkapahi@buckinstitute.org (PK); xmzhang54@yahoo.com (X-MZ); ziyinshen@126.com (Z-YS)

  Affiliation Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China

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• Zi-Yin Shen

  * E-mail: pkapahi@buckinstitute.org (PK); xmzhang54@yahoo.com (X-MZ); ziyinshen@126.com (Z-YS)

  Affiliation Institute of Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China

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