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Open Access
Peer-reviewed
Research Article
Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease
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Javier Simón-Sánchez ,
Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski
Affiliation Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
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Laura L. Kilarski ,
Contributed equally to this work with: Javier Simón-Sánchez, Laura L. Kilarski
Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom
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Michael A. Nalls,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Maria Martinez,
Affiliations Inserm, UMR 1043, Toulouse, France, Paul Sabatier University, Toulouse, France
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Claudia Schulte,
Affiliation Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany
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Peter Holmans,
Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom
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International Parkinson's Disease Genomics Consortium ,
¶a Membership of the International Parkinson's Disease Genomics Consortium is provided in the Acknowledgments.
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Wellcome Trust Case Control Consortium ,
¶b Membership of the Wellcome Trust Case Control Consortium is provided in supporting information.
Affiliation MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom
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Thomas Gasser,
Affiliation Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany
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John Hardy,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Andrew B. Singleton,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Nicholas W. Wood,
Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Alexis Brice,
Affiliations Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR-S975, Paris, France, Inserm, U975, Paris, France, Cnrs, UMR 7225, Paris, France
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Peter Heutink,
Affiliation Section of Medical Genomics, Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands
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Nigel Williams ,
* E-mail: williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)
Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom
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Huw R. Morris
* E-mail: williamsnm@cf.ac.uk (NW); morrishr@cf.ac.uk (HRM)
Affiliations MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff, United Kingdom, Department of Psychological Medicine & Neurology, Cardiff University School of Medicine, Cardiff, United Kingdom
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Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease
- Javier Simón-Sánchez,
- Laura L. Kilarski,
- Michael A. Nalls,
- Maria Martinez,
- Claudia Schulte,
- Peter Holmans,
- International Parkinson's Disease Genomics Consortium,
- Wellcome Trust Case Control Consortium,
- Thomas Gasser,
- John Hardy
- Published: March 12, 2012
- https://doi.org/10.1371/journal.pone.0028787