PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

Roberta Noberini; Sayantan Mitra; Ombretta Salvucci; Fatima Valencia; Srinivas Duggineni; Natalie Prigozhina; Ke Wei; Giovanna Tosato; Ziwei Huang; Elena B. Pasquale

doi:10.1371/journal.pone.0028611

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Open Access

Peer-reviewed

Research Article

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

Roberta Noberini,

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Sayantan Mitra,

Current address: Clontech Laboratories, Inc., Mountain View, California, United States of America

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Ombretta Salvucci,

Affiliation Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Fatima Valencia,

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Srinivas Duggineni,

Affiliation Department of Pharmacology, State University of New York Upstate Cancer Research Institute, State University of New York, Syracuse, New York, United States of America
⨯
Natalie Prigozhina,

Affiliations Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, Biology Department, University of San Diego, San Diego, California, United States of America
⨯
Ke Wei,

Affiliation Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯
Giovanna Tosato,

Affiliation Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ziwei Huang,

Affiliation Department of Pharmacology, State University of New York Upstate Cancer Research Institute, State University of New York, Syracuse, New York, United States of America
⨯
Elena B. Pasquale

* E-mail: elenap@sanfordburnham.org

Affiliations Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America, Department of Pathology, University of California San Diego, San Diego, California, United States of America
⨯

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity

Roberta Noberini,
Sayantan Mitra,
Ombretta Salvucci,
Fatima Valencia,
Srinivas Duggineni,
Natalie Prigozhina,
Ke Wei,
Giovanna Tosato,
Ziwei Huang,
Elena B. Pasquale

Published: December 14, 2011
https://doi.org/10.1371/journal.pone.0028611

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