Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

Haihui Liao; Alan D. Irvine; Caroline J. MacEwen; Kathryn H. Weed; Louise Porter; Laura D. Corden; A. Bethany Gibson; Jonathan E. Moore; Frances J. D. Smith; W. H. Irwin McLean; C. B. Tara Moore

doi:10.1371/journal.pone.0028582

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Open Access

Peer-reviewed

Research Article

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

Haihui Liao,

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
Alan D. Irvine,

Affiliations Department of Paediatric Dermatology, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
⨯
Caroline J. MacEwen,

Affiliation Department of Ophthalmology, Ninewells Hospital & Medical School, Dundee, Scotland
⨯
Kathryn H. Weed,

Affiliation Department of Ophthalmology, Ninewells Hospital & Medical School, Dundee, Scotland
⨯
Louise Porter,

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
Laura D. Corden,

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
A. Bethany Gibson,

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
Jonathan E. Moore,

Affiliation School of Biomedical Sciences, University of Ulster, Coleraine, Ireland, United Kingdom
⨯
Frances J. D. Smith,

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
W. H. Irwin McLean ,

Contributed equally to this work with: W. H. Irwin McLean, C. B. Tara Moore

* E-mail: w.h.i.mclean@dundee.ac.uk

Affiliation Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland
⨯
C. B. Tara Moore

Contributed equally to this work with: W. H. Irwin McLean, C. B. Tara Moore

Affiliations Division of Molecular Medicine, Colleges of Life Sciences and Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland, School of Biomedical Sciences, University of Ulster, Coleraine, Ireland, United Kingdom
⨯

Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

Haihui Liao,
Alan D. Irvine,
Caroline J. MacEwen,
Kathryn H. Weed,
Louise Porter,
Laura D. Corden,
A. Bethany Gibson,
Jonathan E. Moore,
Frances J. D. Smith,
W. H. Irwin McLean

Published: December 12, 2011
https://doi.org/10.1371/journal.pone.0028582

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