Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

Anton Y. Peleg; Spiros Miyakis; Doyle V. Ward; Ashlee M. Earl; Aileen Rubio; David R. Cameron; Satish Pillai; Robert C. Moellering Jr.; George M. Eliopoulos

doi:10.1371/journal.pone.0028316

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Peer-reviewed

Research Article

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

Anton Y. Peleg ,

* E-mail: apeleg@bidmc.harvard.edu

Affiliations Department of Microbiology, School of Biomedical Sciences, Monash University, Melbourne, Australia, Department of Infectious Diseases, The Alfred Hospital, Melbourne, Australia, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Spiros Miyakis,

Affiliations Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, 3rd Department of Medicine, Aristotle University, Thessaloniki, Greece
⨯
Doyle V. Ward,

Affiliation Broad Institute, Boston, Massachusetts, United States of America
⨯
Ashlee M. Earl,

Affiliation Broad Institute, Boston, Massachusetts, United States of America
⨯
Aileen Rubio,

Affiliation Cubist Pharmaceuticals, Boston, Massachusetts, United States of America
⨯
David R. Cameron,

Affiliation Department of Microbiology, School of Biomedical Sciences, Monash University, Melbourne, Australia
⨯
Satish Pillai,

Affiliations Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Robert C. Moellering Jr.,

Affiliations Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
George M. Eliopoulos

Affiliations Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

Anton Y. Peleg,
Spiros Miyakis,
Doyle V. Ward,
Ashlee M. Earl,
Aileen Rubio,
David R. Cameron,
Satish Pillai,
Robert C. Moellering Jr.,
George M. Eliopoulos

Published: January 6, 2012
https://doi.org/10.1371/journal.pone.0028316

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