Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

Linda Sterrenburg; Balázs Gaszner; Jeroen Boerrigter; Lennart Santbergen; Mattia Bramini; Evan Elliott; Alon Chen; Bernard W. M. M. Peeters; Eric W. Roubos; Tamás Kozicz

doi:10.1371/journal.pone.0028128

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Peer-reviewed

Research Article

Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

Linda Sterrenburg,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Balázs Gaszner,

Affiliation Department of Anatomy, Pécs University, Pécs, Hungary
⨯
Jeroen Boerrigter,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Lennart Santbergen,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Mattia Bramini,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Evan Elliott,

Affiliations Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, Faculty of Medicine, Bar Ilan University, Safed, Israel
⨯
Alon Chen,

Affiliation Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
⨯
Bernard W. M. M. Peeters,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Eric W. Roubos,

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯
Tamás Kozicz

* E-mail: t.kozicz@science.ru.nl

Affiliation Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
⨯

Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

Linda Sterrenburg,
Balázs Gaszner,
Jeroen Boerrigter,
Lennart Santbergen,
Mattia Bramini,
Evan Elliott,
Alon Chen,
Bernard W. M. M. Peeters,
Eric W. Roubos,
Tamás Kozicz

Published: November 23, 2011
https://doi.org/10.1371/journal.pone.0028128

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DNA methylation
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Neurons
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Depression
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Immunocytochemistry
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Psychological stress
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Gene expression
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