Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins

Ji Heon Noh; Kwang Hwa Jung; Jeong Kyu Kim; Jung Woo Eun; Hyun Jin Bae; Hong Jian Xie; Young Gyoon Chang; Min Gyu Kim; Won Sang Park; Jung Young Lee; Suk Woo Nam

doi:10.1371/journal.pone.0028103

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Open Access

Peer-reviewed

Research Article

Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins

Ji Heon Noh,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Kwang Hwa Jung,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Jeong Kyu Kim,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Jung Woo Eun,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Hyun Jin Bae,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Hong Jian Xie,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Young Gyoon Chang,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Min Gyu Kim,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Won Sang Park,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Jung Young Lee,

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯
Suk Woo Nam

* E-mail: swnam@catholic.ac.kr.

Affiliation Department of Pathology, College of Medicine and Functional RNomics Research Center, The Catholic University of Korea, Seoul, Korea
⨯

Aberrant Regulation of HDAC2 Mediates Proliferation of Hepatocellular Carcinoma Cells by Deregulating Expression of G1/S Cell Cycle Proteins

Ji Heon Noh,
Kwang Hwa Jung,
Jeong Kyu Kim,
Jung Woo Eun,
Hyun Jin Bae,
Hong Jian Xie,
Young Gyoon Chang,
Min Gyu Kim,
Won Sang Park,
Jung Young Lee

Published: November 23, 2011
https://doi.org/10.1371/journal.pone.0028103

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Hepatocellular carcinoma
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Cell cycle and cell division
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Transfection
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Small interfering RNA
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Cyclins
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Gene expression
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