Automatic Tumor-Stroma Separation in Fluorescence TMAs Enables the Quantitative High-Throughput Analysis of Multiple Cancer Biomarkers

• Bernd Lahrmann,

  Affiliations Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany, Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, Heidelberg, Germany

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• Niels Halama,

  Affiliations Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, Heidelberg, Germany, National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany

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• Hans-Peter Sinn,

  Affiliation Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany

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• Peter Schirmacher,

  Affiliations Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, Heidelberg, Germany, Department of Pathology, University Hospital Heidelberg, Heidelberg, Germany

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• Dirk Jaeger,

  Affiliation National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany

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• Niels Grabe

  * E-mail: niels.grabe@bioquant.uni-heidelberg.de

  Affiliations Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany, Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, Heidelberg, Germany

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