Underestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes

Open Access

Peer-reviewed

Research Article

Sven Stringer ,

* E-mail: s.stringer@umcutrecht.nl

Affiliation Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Naomi R. Wray,

Affiliations Psychiatric Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia, Queensland Brain Institute, University of Queensland, Brisbane, Australia
⨯
René S. Kahn,

Affiliation Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
⨯
Eske M. Derks

Affiliation Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
⨯

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Medical risk factors
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Genome-wide association studies
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Single nucleotide polymorphisms
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Heredity
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Genetics of disease
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Epidemiology
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Probability distribution
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Genetics
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