Replication and Virus-Induced Transcriptome of HAdV-5 in Normal Host Cells versus Cancer Cells - Differences of Relevance for Adenoviral Oncolysis

Dominik E. Dorer; Frank Holtrup; Kurt Fellenberg; Johanna K. Kaufmann; Sarah Engelhardt; Jörg D. Hoheisel; Dirk M. Nettelbeck

doi:10.1371/journal.pone.0027934

Loading metrics

Open Access

Peer-reviewed

Research Article

Replication and Virus-Induced Transcriptome of HAdV-5 in Normal Host Cells versus Cancer Cells - Differences of Relevance for Adenoviral Oncolysis

Dominik E. Dorer ,

Contributed equally to this work with: Dominik E. Dorer, Frank Holtrup

Affiliation Helmholtz-University Group Oncolytic Adenoviruses, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
⨯
Frank Holtrup ,

Contributed equally to this work with: Dominik E. Dorer, Frank Holtrup

Affiliation Division of Functional Genome Analysis, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Heidelberg, Germany
⨯
Kurt Fellenberg,

Affiliations Division of Functional Genome Analysis, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Heidelberg, Germany, Department of Plant Physiology, Ruhr University Bochum, Bochum, Germany
⨯
Johanna K. Kaufmann,

Affiliation Helmholtz-University Group Oncolytic Adenoviruses, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
⨯
Sarah Engelhardt,

Affiliation Helmholtz-University Group Oncolytic Adenoviruses, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
⨯
Jörg D. Hoheisel,

Affiliation Division of Functional Genome Analysis, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Heidelberg, Germany
⨯
Dirk M. Nettelbeck

* E-mail: d.nettelbeck@dkfz.de

Affiliation Helmholtz-University Group Oncolytic Adenoviruses, German Cancer Research Center (Deutsches Krebsforschungszentrum [DKFZ]), Department of Dermatology, Heidelberg University Hospital, Heidelberg, Germany
⨯

Replication and Virus-Induced Transcriptome of HAdV-5 in Normal Host Cells versus Cancer Cells - Differences of Relevance for Adenoviral Oncolysis

Dominik E. Dorer,
Frank Holtrup,
Kurt Fellenberg,
Johanna K. Kaufmann,
Sarah Engelhardt,
Jörg D. Hoheisel,
Dirk M. Nettelbeck

Published: November 30, 2011
https://doi.org/10.1371/journal.pone.0027934

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Melanoma cells
Is the Subject Area "Melanoma cells" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
Viral gene expression
Is the Subject Area "Viral gene expression" applicable to this article?

Thanks for your feedback.
DNA replication
Is the Subject Area "DNA replication" applicable to this article?

Thanks for your feedback.
Skin tumors
Is the Subject Area "Skin tumors" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.