Propofol Inhibits the Activation of p38 through Up-Regulating the Expression of Annexin A1 to Exert Its Anti-Inflammation Effect

Jing Tang; Xi Chen; Weifeng Tu; Yuanbo Guo; Zhenlong Zhao; Qiong Xue; Chunshui Lin; Jinfang Xiao; Xuegang Sun; Tao Tao; Miaoning Gu; Youtan Liu

doi:10.1371/journal.pone.0027890

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Open Access

Peer-reviewed

Research Article

Propofol Inhibits the Activation of p38 through Up-Regulating the Expression of Annexin A1 to Exert Its Anti-Inflammation Effect

Jing Tang ,

Contributed equally to this work with: Jing Tang, Xi Chen

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Xi Chen ,

Contributed equally to this work with: Jing Tang, Xi Chen

Affiliation Department of Anesthesia, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, People's Republic of China
⨯
Weifeng Tu,

Affiliation Department of Anesthesia, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, People's Republic of China
⨯
Yuanbo Guo,

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Zhenlong Zhao,

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Qiong Xue,

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Chunshui Lin,

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Jinfang Xiao,

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Xuegang Sun,

Affiliation The Key Laboratory of Molecular Biology, State Administration of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, People's Republic of China
⨯
Tao Tao ,

* E-mail: gumiaoning@126.com (MG); taotao@126.com (TT); Youtanliuhao@163.com (YL)

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Miaoning Gu ,

* E-mail: gumiaoning@126.com (MG); taotao@126.com (TT); Youtanliuhao@163.com (YL)

Affiliation Department of Anesthesia, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China
⨯
Youtan Liu

* E-mail: gumiaoning@126.com (MG); taotao@126.com (TT); Youtanliuhao@163.com (YL)

Affiliation Department of Anesthesia, Shenzhen Hospital, The University of Hong Kong, Shenzhen, People's Republic of China
⨯

Propofol Inhibits the Activation of p38 through Up-Regulating the Expression of Annexin A1 to Exert Its Anti-Inflammation Effect

Jing Tang,
Xi Chen,
Weifeng Tu,
Yuanbo Guo,
Zhenlong Zhao,
Qiong Xue,
Chunshui Lin,
Jinfang Xiao,
Xuegang Sun,
Tao Tao

Published: December 2, 2011
https://doi.org/10.1371/journal.pone.0027890

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26 Dec 2011
14:50 GMT
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Phosphorylation
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Inflammation
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Monocytes
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Cell signaling
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Endotoxemia
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Protease inhibitor therapy
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