Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients

Getnet Yimer; Nobuhisa Ueda; Abiy Habtewold; Wondwossen Amogne; Akira Suda; Klaus-Dieter Riedel; Jürgen Burhenne; Getachew Aderaye; Lars Lindquist; Eyasu Makonnen; Eleni Aklillu

doi:10.1371/journal.pone.0027810

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Open Access

Peer-reviewed

Research Article

Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients

Getnet Yimer,

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Nobuhisa Ueda,

Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Abiy Habtewold,

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Wondwossen Amogne,

Affiliations Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia, Department of Medicine, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
⨯
Akira Suda,

Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Klaus-Dieter Riedel,

Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
⨯
Jürgen Burhenne,

Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
⨯
Getachew Aderaye,

Affiliation Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Lars Lindquist,

Affiliation Department of Medicine, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden
⨯
Eyasu Makonnen,

Affiliation Department of Pharmacology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Eleni Aklillu

* E-mail: Eleni.Aklillu@ki.se

Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯

Pharmacogenetic & Pharmacokinetic Biomarker for Efavirenz Based ARV and Rifampicin Based Anti-TB Drug Induced Liver Injury in TB-HIV Infected Patients

Getnet Yimer,
Nobuhisa Ueda,
Abiy Habtewold,
Wondwossen Amogne,
Akira Suda,
Klaus-Dieter Riedel,
Jürgen Burhenne,
Getachew Aderaye,
Lars Lindquist,
Eyasu Makonnen

Published: December 6, 2011
https://doi.org/10.1371/journal.pone.0027810

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