NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats

Jiandong Yang; Jin Zheng; Lin Wu; Ming Shi; Hongtao Zhang; Xing Wang; Ning Xia; Desheng Wang; Xinping Liu; Libo Yao; Yan Li; Kefeng Dou

doi:10.1371/journal.pone.0027710

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Open Access

Peer-reviewed

Research Article

NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats

Jiandong Yang ,

Contributed equally to this work with: Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi

Affiliations Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China, Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
⨯
Jin Zheng ,

Contributed equally to this work with: Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi

Affiliation Department of Traditional Chinese and Western Medicine of Oncology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Lin Wu ,

Contributed equally to this work with: Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
⨯
Ming Shi ,

Contributed equally to this work with: Jiandong Yang, Jin Zheng, Lin Wu, Ming Shi

Affiliation Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Hongtao Zhang,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Xing Wang,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Ning Xia,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Desheng Wang,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Xinping Liu,

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
⨯
Libo Yao,

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
⨯
Yan Li ,

* E-mail: lsqfmmu@fmmu.edu.cn (YL); doukef@163.com (KD)

Affiliation Department of Biochemistry and Molecular Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi'an, China
⨯
Kefeng Dou

* E-mail: lsqfmmu@fmmu.edu.cn (YL); doukef@163.com (KD)

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China
⨯

NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats

Jiandong Yang,
Jin Zheng,
Lin Wu,
Ming Shi,
Hongtao Zhang,
Xing Wang,
Ning Xia,
Desheng Wang,
Xinping Liu,
Libo Yao

Published: November 16, 2011
https://doi.org/10.1371/journal.pone.0027710

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Liver fibrosis
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Adenoviruses
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Hepatocytes
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SMAD signaling
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Extracellular matrix
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