Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-Existing Resistance in Chronic Myeloid Leukemia

• Kevin Leder ,

  Contributed equally to this work with: Kevin Leder, Jasmine Foo

  Affiliation Program for Industrial and Systems Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Jasmine Foo ,

  Contributed equally to this work with: Kevin Leder, Jasmine Foo

  Affiliation School of Mathematics, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Brian Skaggs,

  Affiliation Division of Rheumatology, David Geffen University of California Los Angeles School of Medicine, Los Angeles, California, United States of America

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• Mercedes Gorre,

  Affiliation Combimatrix, Irvine, California, United States of America

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• Charles L. Sawyers,

  Affiliation Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Franziska Michor

  * E-mail: michor@jimmy.harvard.edu

  Affiliation Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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