The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

Kazushiro Takata; Makoto Kinoshita; Tatsusada Okuno; Masayuki Moriya; Tohru Kohda; Josephe A. Honorat; Tomoyuki Sugimoto; Atsushi Kumanogoh; Hisako Kayama; Kiyoshi Takeda; Saburo Sakoda; Yuji Nakatsuji

doi:10.1371/journal.pone.0027644

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Open Access

Peer-reviewed

Research Article

The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

Kazushiro Takata,

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Makoto Kinoshita,

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Tatsusada Okuno,

Affiliations Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan
⨯
Masayuki Moriya,

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Tohru Kohda,

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Josephe A. Honorat,

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Tomoyuki Sugimoto,

Current address: Hirosaki University Graduate School of Science and Technology, Hirosaki, Aomori, Japan

Affiliation Department of Bio-medical statistics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯
Atsushi Kumanogoh,

Affiliation World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan
⨯
Hisako Kayama,

Affiliation Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
⨯
Kiyoshi Takeda,

Affiliation Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
⨯
Saburo Sakoda,

Affiliation Department of Neurology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan
⨯
Yuji Nakatsuji

* E-mail: yuji@neurol.med.osaka-u.ac.jp

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
⨯

The Lactic Acid Bacterium Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells

Kazushiro Takata,
Makoto Kinoshita,
Tatsusada Okuno,
Masayuki Moriya,
Tohru Kohda,
Josephe A. Honorat,
Tomoyuki Sugimoto,
Atsushi Kumanogoh,
Hisako Kayama,
Kiyoshi Takeda

Published: November 15, 2011
https://doi.org/10.1371/journal.pone.0027644

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