Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

Open Access

Peer-reviewed

Research Article

Aishe Chen ,

Contributed equally to this work with: Aishe Chen, Lixue Dong

Affiliation Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
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Lixue Dong ,

Contributed equally to this work with: Aishe Chen, Lixue Dong

Affiliation Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
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Nancy R. Leffler,

Affiliation Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America
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Adam S. Asch,

Affiliations Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States of America
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Owen N. Witte,

Affiliation Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California, United States of America
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Li V. Yang

* E-mail: yangl@ecu.edu

Affiliations Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America, Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States of America, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States of America
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Acidosis
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Cell adhesion
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Endothelial cells
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Adhesion molecules
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MicroRNAs
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G-protein signaling
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Inflammation
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Reverse transcriptase-polymerase chain reaction
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