8-Modified-2′-Deoxyadenosine Analogues Induce Delayed Polymerization Arrest during HIV-1 Reverse Transcription

Valérie Vivet-Boudou; Catherine Isel; Marwan Sleiman; Redmond Smyth; Nouha Ben Gaied; Patrick Barhoum; Géraldine Laumond; Guillaume Bec; Matthias Götte; Johnson Mak; Anne-Marie Aubertin; Alain Burger; Roland Marquet

doi:10.1371/journal.pone.0027456

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Open Access

Peer-reviewed

Research Article

8-Modified-2′-Deoxyadenosine Analogues Induce Delayed Polymerization Arrest during HIV-1 Reverse Transcription

Valérie Vivet-Boudou ,

Contributed equally to this work with: Valérie Vivet-Boudou, Catherine Isel

* E-mail: v.vivet@ibmc-cnrs.unistra.fr (VVB); c.isel@ibmc-cnrs.unistra.fr (CI)

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯
Catherine Isel ,

Contributed equally to this work with: Valérie Vivet-Boudou, Catherine Isel

* E-mail: v.vivet@ibmc-cnrs.unistra.fr (VVB); c.isel@ibmc-cnrs.unistra.fr (CI)

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯
Marwan Sleiman,

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯
Redmond Smyth,

Affiliation Centre for Virology, Burnet Institute, Melbourne, Australia
⨯
Nouha Ben Gaied,

Affiliation Laboratoire de Chimie des Molécules Bioactives et des Arômes, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, Centre National de la Recherche Scientifique, Nice, France
⨯
Patrick Barhoum,

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯
Géraldine Laumond,

Affiliation Laboratoire de Virologie, Faculté de Médecine, Université de Strasbourg, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
⨯
Guillaume Bec,

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯
Matthias Götte,

Affiliation Department of Biochemistry, McGill University, Montreal, Canada
⨯
Johnson Mak,

Affiliation Centre for Virology, Burnet Institute, Melbourne, Australia
⨯
Anne-Marie Aubertin,

Affiliation Laboratoire de Virologie, Faculté de Médecine, Université de Strasbourg, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France
⨯
Alain Burger,

Affiliation Laboratoire de Chimie des Molécules Bioactives et des Arômes, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, Centre National de la Recherche Scientifique, Nice, France
⨯
Roland Marquet

Affiliation Architecture et Réactivité de l'ARN, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, Centre National de la Recherche Scientifique, Strasbourg, France
⨯

8-Modified-2′-Deoxyadenosine Analogues Induce Delayed Polymerization Arrest during HIV-1 Reverse Transcription

Valérie Vivet-Boudou,
Catherine Isel,
Marwan Sleiman,
Redmond Smyth,
Nouha Ben Gaied,
Patrick Barhoum,
Géraldine Laumond,
Guillaume Bec,
Matthias Götte,
Johnson Mak

Published: November 7, 2011
https://doi.org/10.1371/journal.pone.0027456

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