Mitochondrial-Associated Cell Death Mechanisms Are Reset to an Embryonic-Like State in Aged Donor-Derived iPS Cells Harboring Chromosomal Aberrations

• Alessandro Prigione,

  Affiliation Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Amir M. Hossini,

  Affiliation Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

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• Björn Lichtner,

  Affiliation Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Akdes Serin,

  Affiliation Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Beatrix Fauler,

  Affiliation Electron Microscopy Group, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Matthias Megges,

  Affiliation Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Rudi Lurz,

  Affiliation Electron Microscopy Group, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Hans Lehrach,

  Affiliation Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany

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• Eugenia Makrantonaki ,

  Contributed equally to this work with: Eugenia Makrantonaki, James Adjaye

  Affiliations Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany, Institute of Clinical Pharmacology and Toxicology, Charité University Medicine, Berlin, Germany

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• Christos C. Zouboulis ,

  * adjaye@molgen.mpg.de

  Affiliation Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

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• James Adjaye

  Contributed equally to this work with: Eugenia Makrantonaki, James Adjaye

  * adjaye@molgen.mpg.de

  Affiliations Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, The Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia

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