Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEB

Mulualem E. Tilahun; Alan Kwan; Kannan Natarajan; Megan Quinn; Ashenafi Y. Tilahun; Chen Xie; David H. Margulies; Barbara A. Osborne; Richard A. Goldsby; Govindarajan Rajagopalan

doi:10.1371/journal.pone.0027203

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Peer-reviewed

Research Article

Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEB

Mulualem E. Tilahun,

Affiliations Department of Biology, Amherst College, Amherst, Massachusetts, United States of America, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America
⨯
Alan Kwan,

Affiliation Department of Biology, Amherst College, Amherst, Massachusetts, United States of America
⨯
Kannan Natarajan,

Affiliation Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Megan Quinn,

Affiliation Department of Biology, Amherst College, Amherst, Massachusetts, United States of America
⨯
Ashenafi Y. Tilahun,

Affiliation Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Massachusetts, United States of America
⨯
Chen Xie,

Affiliation Department of Biology, Amherst College, Amherst, Massachusetts, United States of America
⨯
David H. Margulies,

Affiliation Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Barbara A. Osborne,

Affiliation Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America
⨯
Richard A. Goldsby ,

* E-mail: Rajagopalan.Govindarajan@mayo.edu (GR); ragoldsby@amherst.edu (RAG)

Affiliations Department of Biology, Amherst College, Amherst, Massachusetts, United States of America, Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America
⨯
Govindarajan Rajagopalan

* E-mail: Rajagopalan.Govindarajan@mayo.edu (GR); ragoldsby@amherst.edu (RAG)

Affiliation Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Massachusetts, United States of America
⨯

Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEB

Mulualem E. Tilahun,
Alan Kwan,
Kannan Natarajan,
Megan Quinn,
Ashenafi Y. Tilahun,
Chen Xie,
David H. Margulies,
Barbara A. Osborne,
Richard A. Goldsby,
Govindarajan Rajagopalan

Published: November 15, 2011
https://doi.org/10.1371/journal.pone.0027203

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