Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice

• Michael P. Siegel,

  Affiliation Department of Bioengineering, University of Washington Medical School, Seattle, Washington, United States of America

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• Shane E. Kruse,

  Affiliation Department of Radiology, University of Washington Medical School, Seattle, Washington, United States of America

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• Gary Knowels,

  Affiliation Department of Radiology, University of Washington Medical School, Seattle, Washington, United States of America

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• Adam Salmon,

  Affiliation Department of Cellular and Structural Biology, University of Texas Health Sciences Center, San Antonio, Texas, United States of America

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• Richard Beyer,

  Affiliation Department of Environmental and Occupational Health Sciences, University of Washington Medical School, Seattle, Washington, United States of America

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• Hui Xie,

  Affiliation Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford-Burnham Medical Research Institute, Winter Park, Florida, United States of America

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• Holly Van Remmen,

  Affiliation Department of Cellular and Structural Biology, University of Texas Health Sciences Center, San Antonio, Texas, United States of America

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• Steven R. Smith,

  Affiliation Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford-Burnham Medical Research Institute, Winter Park, Florida, United States of America

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• David J. Marcinek

  * E-mail: dmarc@uw.edu

  Affiliations Department of Bioengineering, University of Washington Medical School, Seattle, Washington, United States of America, Department of Radiology, University of Washington Medical School, Seattle, Washington, United States of America

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